Difference between blastocysts of d5 and d6

Patient's question:

My husband and I are using IVF. I heard there are two types of blastocysts, D5 and D6. Could you please tell me the difference between D5 and D6 blastocysts?

Doctor's answer:

After the early embryo stage, by the 5th or 6th day, the embryo develops into hundreds of cells and transforms into a blastocyst. Although blastocysts can also be graded, it's important to know that even the lowest-grade blastocysts have a higher implantation rate compared to fresh embryo transfer. A Day 5 blastocyst is an embryo that is in the process of hatching, while a Day 6 blastocyst is fully hatched. Both are relatively fragile because they lack the protection of the zona pellucida, making them prone to death or damage during the freezing and thawing process.

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