Application of Biostatistics in Experimental and Clinical Pharmacology

Author: Xu Dianzheng
Publisher:
Publish Date: 2004-08-01
Features: This book is suitable for professionals engaged in biostatistics, biomedical, clinical pharmacy, and pharmaceutical production, as well as teachers, graduate students, and undergraduates in related fields at universities. It focuses on introducing the fundamental theories of biostatistics and their applications in experimental and clinical pharmacology. The book is divided into two parts, with the first part leaning toward experimental pharmacology. Main topics include: hypothesis testing, intergroup comparisons, regression and correlation, experimental design and analysis of variance, factorial design, multiple linear regression and multiple correlation, covariance analysis, tests, nonparametric methods, bioassay, median effective dose, continuous sequential trials, and evaluation of drug interactions. The second part leans toward clinical pharmacology. Main topics include: basic principles of clinical drug trials (including control, randomization, blinding, and placebo), sample size determination, crossover design, drug equivalence trials, repeated measures split-plot design, pharmacoeconomics, subgroup analysis, diagnostic tests, odds ratio and relative risk analysis, consistency tests, survival curves and Logrank tests, multiple regression, logistic regression, Cox proportional hazards regression analysis, Mantel-Haenszel tests, meta-analysis, interim analyses, and group sequential trials.