New Theories and New Methods of Therapeutic Drug Monitoring

Author: Ling Shusen
Publisher:
Publish Date: 2002-01-01
Features: Based on the author's research work and combined with the latest research trends in therapeutic drug monitoring, this book introduces the objectives, methods, significance, and application prospects of population pharmacokinetic research. It covers the functions and usage of nonlinear mixed-effects modeling (NONMEM) programs, basic concepts of clinical pharmacodynamics, and pharmacokinetic-pharmacodynamic combined analysis. Additionally, it discusses enantiomer-specific pharmacokinetics and pharmacodynamics, the relationship between pharmacogenetics, pharmacogenomics, and personalized therapy and rational clinical drug use. The book also explores pharmacists' clinical practice with patient individuals as the monitoring subjects, methods and implementation of therapeutic drug monitoring quality control, an overview of pharmacoeconomics, and aspects such as the methods, experimental design, and statistical analysis of new drug clinical trials.
As pharmacotherapy evolves from formulaic treatment to personalized therapy and the integration of pharmaceutical care, therapeutic drug monitoring and rational drug use continue to develop with the advancement of related disciplines such as mathematics, computer technology, analytical techniques, molecular biology, and pharmacogenetics. New theories and methods have emerged. Based on our research work and combined with the latest research trends in therapeutic drug monitoring, this book introduces the objectives, methods, significance, and application prospects of population pharmacokinetic research, the functions and usage of nonlinear mixed-effects modeling (NONMEM) programs, basic concepts of clinical pharmacodynamics, and pharmacokinetic-pharmacodynamic combined analysis. It also covers enantiomer-specific pharmacokinetics and pharmacodynamics, the relationship between pharmacogenetics, pharmacogenomics, and personalized therapy and rational clinical drug use, pharmacists' clinical practice with patient individuals as the monitoring subjects, methods and implementation of therapeutic drug monitoring quality control, an overview of pharmacoeconomics, and aspects such as the methods, experimental design, and statistical analysis of new drug clinical trials.
The purpose of this book is to promote the development of therapeutic drug monitoring, optimize individual drug use and treatment, and improve the level of rational clinical drug use. It serves as a reference for medical and pharmaceutical professionals engaged in clinical pharmacology, clinical pharmacy, therapeutic drug monitoring, and related research.