Peptide nucleic acid

Author: He Wei
Publisher:
Publish Date: 2003-08-01
Features: Peptide nucleic acid (PNA) is a unique compound with a neutral amide bond as its backbone and possessing properties of both peptides and nucleic acids. It can bind to DNA and RNA with high affinity and sequence-specificity, and the formed hybrid complexes exhibit considerable thermal stability as well as unique resistance to changes in ionic strength. PNA is not degraded by proteases or nucleases. This book was compiled by collecting literature on PNA published up to December 2002, along with relevant materials found on the internet. It provides a detailed exposition of the chemistry of PNA, the hybridization properties of PNA, its applications as a molecular biology tool, its potential applications as antisense and anti-gene agents, its applications in the field of diagnostics, and its use in biochips and biosensors. The book is highly practical, with detailed descriptions of experimental design and procedures for some experiments, making it suitable for reference by professionals in the fields of molecular biology, life sciences, drug research, clinical diagnostics, environmental testing, and related areas.