What diseases cannot pass through the placenta, newborns are prone to Gram-negative

Patient's question:

No

Doctor's answer:

Immunoglobulin ZgM cannot cross the placenta to the fetus, while immunoglobulin M is the main antibody against Gram-negative bacteria (such as E. coli), so newborns are prone to E. coli infections (such as E. coli meningitis, sepsis).