Can parents with chromosomal abnormalities have normal children?

Patient's question:

The female has a Robertsonian translocation involving chromosomes 15 and 22, and the male has an inversion of chromosome 9. Can they have children?

Doctor's answer:

Analysis of the condition: Hello! Chromosomal abnormalities in both parents, the probability of their sperm and eggs being normal is very low, and it is generally very likely that the fetus they carry will have a chromosomal disease.
Suggestions: Generally, it is not recommended to have children in this situation. You can go to the hospital for a pre-pregnancy evaluation.

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