My Down syndrome screening PAPP-A is below normal value

Patient's question:

I am 28 years old this year. I had a prenatal screening at 11 weeks + 2, which tested for PAPP-A and F-βHCG. The screening results showed low risks for both Trisomy 21 and Trisomy 18. The hCG levels were also within the normal range, but the PAPP-A result was 623.14 mU/L, with a corrected MoM of 0.30 (the normal range is 0.43). The hospital's report suggested consulting an expert at the municipal maternal and child hospital.
Is my situation serious? I am very worried. How can I improve this value? Will this lead to the inheritance of any diseases?

Doctor's answer:

Analysis of the condition: It is difficult to clearly determine the impact on the fetus based on a single result, but a comprehensive judgment of the three indicators still falls into the category of lower-risk pregnancy.
Advice: It is recommended to conduct a thorough ultrasound examination of the fetus at around 20 weeks to identify whether any malformations are present. Additionally, it is necessary to further investigate whether there is a family history of genetic diseases, whether the individual has other diseases, and the status of previous pregnancy history.
Doctor's inquiry:

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