Patient's question:
What is Honer's syndrome? How should people with this disease be treated?Doctor's answer:
If treated actively, female characteristics are basically the same as those of normal women, but they cannot bear children. Congenital hypoplasia of the ovaries, also known as Turner's syndrome (Turer), is a disease caused by a congenital chromosomal abnormality. Normal female chromosomes are 46,XX. If the karyotype is 45,XO, meaning one sex chromosome X is missing, or 46,XXp, 46,XXq, or their mosaics, it can be diagnosed as Turner's syndrome. Due to the abnormal sex chromosomes, the ovaries cannot grow and develop, so the ovaries appear as fibrous tissue in the form of strands, without primordial follicles or oocytes. Clinical features include short stature, rarely exceeding 150 cm in height after adulthood, a low hairline on the neck, which may even reach the shoulders, a short and thick neck. More than half of the patients have loose neck skin, forming a webbed neck from the mastoid process behind the ear to the shoulder tip. The chest is broad and shield-like, the elbows are outwardly deviated, the nipples are displaced, congenital aortic stenosis, amenorrhea, and underdevelopment of secondary sexual characteristics. FSH levels in the body are elevated, while estrogen levels are extremely low. Various types of mosaics, such as 45,XO/46,XX, 45,XO/47,XXX, etc., these mosaic cases are closer to normal women than the 45,XO type. Some patients may occasionally experience menstruation, breast development, or even pregnancy, but with a high rate of miscarriage and stillbirth. No treatment can promote ovarian development or restore fertility in patients. The goal of treatment is to promote height, stimulate breast and reproductive organ development. How to treat female sexual underdevelopment