Patient's question:
I have had 3 experiences of miscarriage, each time at 50 days when I did a chromosome test.Doctor's answer:
Symptom Analysis: Chromosome Report Analysis:1. The chromosome is 45, XX, rob? (13;14) refers to suspected Robertsonian translocation between chromosome 13 and chromosome 14. This is a chromosomal genetic disease. Pregnancy is allowed, but it must be under the supervision of a specialist doctor, with guidance on reproduction. During pregnancy, chorionic villus or amniotic fluid chromosome testing should be performed. If fetal chromosomal abnormalities are detected, pregnancy should be terminated early. In summary, when miscarriage symptoms appear during pregnancy, it should not be blindly preserved. It should be regarded as a natural selection, which is an eugenic choice mechanism.
2. 46, XY21S+ refers to the male having an extra 21 chromosome (S+), which is a chromosomal polymorphism. It has little impact on the individual himself but may increase the early pregnancy miscarriage rate in the wife. If the pregnancy reaches the second trimester, the risk of congenital defects in the fetus is generally low. The fetus has a 50% chance of inheriting the 21 chromosome S+. The genetic risk is the same as that of the father.
Guidance: Both partners' chromosome test reports show abnormal conditions. The three cases of embryonic arrest are relatively related to this. If it can be confirmed that the embryonic arrest is caused by chromosomal abnormal carriers, there is currently no effective treatment in Western medicine. Only prenatal genetic counseling and diagnosis can be performed.