Patient's question:
All symptoms of stomach pain and bloating 2000Doctor's answer:
Disease Analysis: Gastritis is a chronic superficial inflammation of the gastric mucosa, being the most common type of chronic gastritis, accounting for approximately 50% to 85% of all chronic gastritis cases detected during endoscopic examinations. The peak onset age for this condition is between 31 and 50 years old, with males being more affected than females. The basic pathological changes of gastritis include epithelial cell degeneration, crypt epithelial hyperplasia, and inflammatory cell infiltration in the lamina propria. Occasionally, intestinal metaplasia of surface epithelium and crypt epithelium may be observed without a reduction in the number of. The affected areas are often most prominent in the antrum and are usually diffuse. Endoscopic examination reveals congestion, edema, and pinpoint hemorrhages with erosions or yellowish-white mucous exudates in the gastric mucosa.Guidance: The pharmacological treatment for superficial gastritis can generally be divided into two categories: drugs that protect the gastric mucosa and drugs that eliminate factors that damage the gastric mucosa.
Drugs for Gastric Mucosal Protection:
1. Cimetidine: A succinate hemiesters derived from glycyrrhizinic acid, it enhances gastric mucosal mucus secretion, prolongs the lifespan of gastric epithelial cells, and mildly inhibits the activity of pepsin, thus protecting the gastric mucosa from bile damage and preventing H+ back diffusion.
- Dosage: 100 mg, three times daily. After 2 weeks, reduce to 50 mg, three times daily, taken half an hour before meals. A course of 4–5 weeks is recommended.
- Side effects: Fluid and sodium retention, so it is advisable to take hydrochlorothiazide and potassium supplements concurrently.
2. Sucralfate: This drug complexes with pepsin, inhibiting its proteolytic activity, and forms a protective film with gastric mucosal proteins, blocking the penetration and erosion of gastric acid, pepsin, and bile acids. Additionally, it promotes the metabolism of gastric mucosal cells.
- Dosage: 1.0 g, three to four times daily.
3. Mucosolvan-S Granules: This drug contains water-soluble B334 and L-glutamine. Water-soluble B334 directly acts on the gastric mucosa to eliminate local inflammation. L-glutamine, together with hexosamine and glucosamine (components of gastrointestinal mucosal epithelium), participates in tissue repair to achieve therapeutic goals.
- Dosage: 670 mg, three times daily.
4. Gastritis Dry Syrup: This drug primarily consists of gentamicin sulfate, procaine hydrochloride, and vitamin B12, among other components. It has anti-inflammatory, analgesic, and mucosal repair-promoting effects.
- Dosage: 5 g, three times daily.
5. Smecta: This drug has strong binding properties against bacteria and viruses and exhibits strong coverage ability for gastrointestinal mucosa. By interacting with mucus, it enhances the tensile strength of gastrointestinal mucosal gelatin to resist various attacking factors.
- Dosage: 3 g, three times daily.
6. Others:
- Viosterol (2–4 tablets), three times daily.
- Gastric membrane (2–3 g), three times daily.
- Aluminum hydroxide gel (10 mg), three times daily.
- Gastric antacid (4 tablets), three times daily.
- Prostaglandin E2 (50–150 mg), three times daily.
All of these can help protect and improve the gastric mucosa.
Lifestyle Care: Patients with superficial gastritis should follow a light, regular, and scheduled diet with fixed quantities, avoiding overly acidic, spicy, cold, or rough foods.