What should women with O-type blood pay attention to when giving birth?

Patient's question:

Gender: Female
Age: 28
My wife is O-negative. I heard that women with O-negative blood type need to undergo some kind of blood breakdown process before giving birth and need to get injections. Could you please explain what this is about?
If our blood types are different, can we still have children? I’m not sure what my blood type is.

Doctor's answer:

Analysis of the condition: Mismatched blood types between the mother and father may cause neonatal hemolytic disease. Neonatal hemolytic disease refers to a hemolytic disorder caused by a blood type mismatch between the mother and child. The most common types are ABO blood type mismatches, while Rh blood type mismatches are less common, and other blood type mismatches occasionally occur. The blood types of individuals affected by hemolysis include A, B, AB, and O types.
Advice: Infants with a mother who is type O and a father who is type AB are most prone to developing the disease. This primarily depends on the possible genotype of the child. If you are heterozygous and the child is type O, then there is no need to worry.