Fibrosis disease: Basic and clinical aspects

Author: Gao Chunfang
Publisher:
Publish Date: 2004-03-01
Features: Based on a thorough elaboration of the material basis of fibrosis—three extracellular matrices (collagen, glycoprotein, proteoglycan)—regarding their structures and biochemical characteristics, this book explores the abnormal expression and regulation of these extracellular matrix components under pathological conditions from different perspectives, including cytology, immunology, and molecular biology, with hepatic fibrosis as the early change of liver cirrhosis. It particularly focuses on the transcriptional regulation mechanisms of collagen genes, which are relatively less studied domestically, integrating the latest research progress and findings both domestically and internationally. At the level of gene switches, it provides a systematic discussion on the regulatory mechanisms of fibrosis and sclerosis, offering experimental evidence and partial screening methods for the selection of clinical therapeutic drugs. Additionally, the book provides detailed introductions to the formation mechanisms, pathological features, diagnosis, treatment, and preparation of animal (cell) models for fibrosis in major organs and tissues such as the liver, kidneys, lungs, pancreas, skin, cardiovascular system, bone marrow, and central nervous system. The close integration of basic research and clinical applications, along with its strong originality, are key features of this book, enabling readers to better understand the fundamental and clinical characteristics of fibrosis in both breadth and depth. This book can serve as a reference for clinicians in various disciplines. Furthermore, due to its extensive coverage of cytology, immunology, and molecular biology theories and techniques, it can also provide research insights and methodological references for researchers engaged in related basic studies.