How is pediatric malignant mixed germ cell tumor treated?

Patient's question:

Children, 1Y9M, on November 18, 2014, were diagnosed with an abdominal mass discovered about 10 days prior and underwent resection of a retroperitoneal mixed germ cell tumor. The tumor measured approximately 10cm8cm7.6cm. Microscopic description: a cystic and solid mass, with well-differentiated squamous epithelial tissue, neuroglial tissue, and occasional endodermal sinus tumor structures accounting for 40%. Pathological diagnosis: (retroperitoneum) malignant mixed germ cell tumor. Immunohistochemical staining results: Vimentin(+)、AFP(+)、EMA(+)、CK(-)、PLAP(+). Two weeks post-surgery, JEB regimen chemotherapy was administered: D1 "Bleomycin (6.5mg) + VP16 (0.035g); D2-4" Carboplatin (90mg) + VP16 (0.035g)". Preoperative AFP level was 7000, pre-chemotherapy AFP was 400. Postoperative ultrasound, electrocardiogram, and CT scans showed: no palpable enlargement of superficial lymph nodes; regular heart rhythm, normal heart sounds, no pathological murmurs; coarse breath sounds in both lungs, no dry or wet rales; soft abdomen, surgical scars visible on the abdominal wall, no redness, swelling, or tenderness, no significant palpable mass.

Doctor's answer:

A general answer cannot be given to your question. It requires a comprehensive evaluation of the baby's disease stage based on observations during surgery, the surgical condition, postoperative pathology, etc., to determine the appropriate chemotherapy plan.

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