Patient's question:
At the age of 5 months, breast development was observed, and bone age was 1 year older. At that time, height was 138 cm, and weight was 32 kg, with no treatment administered. Now at 9 months, bone age is 11.2 years, which is 1.5 years older than chronological age. Current height is 149 cm, and weight is 40 kg.Doctor's answer:
If pituitary MRI can rule out hypothalamic and pituitary lesions, triptorelin acetate (e.g., Decapeptyl) can be considered to suppress the already initiated pubertal development, delay the onset of menarche, reduce the impact of sex hormones on bones, and delay the closure of growth plates. It should be noted that with the suppression of sex hormones, the rapid height growth brought by sex hormones will also be affected, and the rate of height growth will slow down. However, the slowed height growth rate can be compensated by extending the duration of height growth, so the pros and cons of using or not using the medication should be weighed. The slowed height growth caused by Decapeptyl can be appropriately compensated with growth hormone, but it also requires a significant treatment cost. These issues should be considered before treatment, taking into account the family's financial situation to make a decision. The use of drugs like Decapeptyl must be under the guidance of a specialist and regular monitoring of sex hormones, bone age, height, secondary sexual characteristics, uterine and ovarian changes is necessary to determine the timing of medication. The professional level of the Endocrinology Department at Chongqing Children's Hospital should be able to address these issues, and local treatment and follow-up will also be more convenient.