Is it bad for women with Type O blood to get pregnant?

Patient's question:

I am a female with O negative blood type. I heard that this blood type is not good for pregnancy and can cause problems. Is that true? What are the downsides?

Doctor's answer:

Analysis of the condition: ABO hemolysis refers to the tendency for women to be type O and men to be type A or B to experience hemolysis. Due to a mismatch in blood types between the fetus and the mother, antibodies are produced, leading to hemolysis. This type of hemolysis often occurs in the first pregnancy. If the male partner was also type B in the first marriage, the likelihood of hemolysis in subsequent pregnancies is lower.
Advice: After pregnancy, fetal umbilical cord blood testing can be performed to determine if hemolysis is present. If jaundice occurs after the baby is born, the possibility of hemolysis should be considered. It is recommended to consult with a reproductive genetics center before pregnancy for guidance.

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