Does taking growth hormone cause weight gain?

Patient's question:

A child is short and needs to take growth hormone to grow taller. Will they gain weight after taking growth hormone?
What kind of help you care about: A child is short and needs to take growth hormone to grow taller. Will they gain weight after taking growth hormone?

Doctor's answer:

Growth hormone not only promotes the growth of epiphyses but also has the effect of compressing fat, and it will never lead to weight gain. Human growth hormone is a peptide hormone secreted by the anterior lobe of the pituitary gland, composed of 191 amino acids. It is the most important hormone promoting growth after birth. The increase in height in children is mainly achieved through the cell division of chondrocytes in the growth plate between the diaphysis and epiphysis of long bones, and growth hormone significantly promotes the differentiation and cell division of these chondrocytes.

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