Patient's question:
31-week premature infant, hospitalized for one month, with repeated jaundice before discharge. Tests: Cytomegalovirus IgM antibody (CMV-IgM) 41.17 COI, Cytomegalovirus (CMV-IgG) 105.3 IU/mLDoctor's answer:
Giant cell virus infection in pregnant mothers can invade the fetus through the placenta, causing congenital infection. In a few cases, it may lead to premature birth, miscarriage, stillbirth, or postnatal death. Affected infants may develop jaundice, hepatosplenomegaly, thrombocytopenic purpura, and hemolytic anemia. Surviving children often have permanent intellectual disability, neuromuscular motor disorders, deafness, and chorioretinitis. Treatment medications include ganciclovir and fluconazole tablets.