Patient's question:
My girlfriend's grandmother has a mental illness, but she has borne two daughters without any issues. My girlfriend is perfectly normal, but I'm wondering if our future children will inherit this condition. I hope professionals can help analyze this. Please don't just copy and paste; I'd like a professional perspective on this matter. Currently, my mother strongly opposes our relationship, and I'm very upset. I sincerely hope everyone can help me. Thank you!Doctor's answer:
During the pre-marital health check-up, you should have a medical examination at the hospital. From a biological perspective, this disease is an inherited recessive genetic disorder. Your girlfriend's grandmother's genetic predisposition to mental illness is recessive, which can be denoted as aa. Her grandfather should be AA. Therefore, their two daughters should be Aa, carrying one recessive gene. Your fiancé could be either AA or Aa, and your girlfriend could be either AA or Aa, as her mother carries one recessive a. If your family has no history of mental illness, the likelihood of you carrying an a is low. Thus, in general, the probability of your children having the disease is relatively small, mainly depending on whether you carry the a gene. If you are AA, there would be no issues at all.