Will kidney disease be inherited across generations?

Patient's question:

My husband has been experiencing lower back pain recently. After playing mahjong for 4 hours, his lower back gets very sore. His father had acute kidney disease before getting married. Neither he nor his sister has kidney disease, but both of his sister's children have kidney disease, which they were born with. They have been treated, but it eventually developed into uremia. A 23-year-old girl and a 12-year-old boy from his sister's family passed away. The daughter he is raising is in good health. Now that he is experiencing lower back pain, is it possible that both he and his sister carry a recessive gene? If he were raising a son, would there be a 50% chance of inheritance?

Doctor's answer:

Okay, here is the translation following your instructions:
That depends on the type of kidney disease. Generally, kidney disease is not hereditary. Suggestions: 1. It's not necessarily hereditary that his sister's child has it; it might also have something to do with his husband. 2. Sitting for several hours at a time will surely cause some lower back pain. However, because there are many such patients in the family, for the sake of caution, it's a good idea to get a kidney function test. It's not necessarily kidney disease that has been inherited. There are many factors that can cause pediatric kidney disease. If the child is confirmed to have pediatric kidney disease, parents need to cooperate with the doctor to start treatment immediately, cooperate with gastrointestinal decompression, and develop good hygiene habits. The child needs a reasonable diet and should avoid stimulating and cold foods.

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