What are the side effects of nitrofurantoin enteric-coated tablets?

Patient's question:

My baby is three years old. After a thorough examination, it was found to be a urinary tract infection, and I was prescribed Furadantin enteric-coated tablets at the hospital. The medication started on January 27th in the afternoon, with half a tablet each time. After taking it for two days on January 28th and 29th, the baby began to develop a high fever of 39 degrees and symptoms such as a red throat. On January 30th in the morning...

Doctor's answer:

Here is the English translation of the provided text, with line breaks retained as instructed:
Adverse Reactions:
1. Nausea, dry cough, poor appetite, and nausea with vomiting are relatively common gastrointestinal reactions.
2. Allergic reactions such as rash, drug fever, leukopenia, hepatitis, and hemolytic anemia (in patients with glucose-6-phosphate dehydrogenase deficiency) may recur.
3. Neurological adverse reactions like headache, dizziness, anorexia, muscle pain, and nystagmus may occasionally occur, most of which are reversible. Severe cases may lead to peripheral neuropathy, especially in patients with pre-existing renal impairment or those taking this medication long-term.
4. Furan may occasionally cause acute pneumonia symptoms such as fever, cough, chest pain, pulmonary infection, and eosinophilia, which usually resolve quickly after discontinuation. Corticosteroids may be used to alleviate symptoms in severe cases. Long-term use (over 6 months) may lead to interstitial pneumonia or pulmonary fibrosis, requiring early discontinuation and appropriate treatment.
Medical Advice:
[Precautions]
1. Furan should be taken with food to reduce gastrointestinal irritation.
2. The treatment duration should be at least 7 days, or until bacterial clearance in the urine is confirmed for more than 3 days.
3. Long-term use (over 6 months) may increase the risk of diffuse interstitial pneumonia or pulmonary fibrosis. Close monitoring is recommended for early detection and timely discontinuation. Therefore, long-term prophylactic use should be carefully weighed against potential risks.
4. Use with caution in patients with glucose-6-phosphate dehydrogenase deficiency, peripheral neuropathy, or pulmonary diseases.
5. Impact on Laboratory Tests: This medication may affect urine glucose tests, as its metabolites in urine can cause false-positive reactions with the copper sulfate reagent.
The above advice is for the question "Adverse Reactions of Furan Enteric-Coated Tablets." I hope it helps you. Wishing you good health!
(Note: "Furan" is retained as a proper medication name, with "" transliterated for clarity if needed.)

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