What are the reasons for abnormal organic acid metabolism?

Patient's question:

The baby just born doesn't need newborn screening, right? Just received the results today saying there's an abnormality in organic acid catabolism. What's going on? What kind of assistance is needed: Just received the results today saying there's an abnormality in organic acid catabolism, what's going on?...

Doctor's answer:

It refers to many organic compounds that possess acidity. The most common organic acids are carboxylic acids, whose acidity originates from the carboxyl group (-COOH). Sulfonic acids (-SO3H), sulfenic acids (RSOOH), and thioesters (RCOSH) also belong to organic acids. Organic acids can react with alcohols to form esters.
Generally, it is believed that aliphatic organic acids lack special biological activity, but some organic acids, such as tartaric acid and citric acid, are used in medicine. It has also been reported that malic acid, citric acid, tartaric acid, and ascorbic acid, when evaluated collectively, have efficacy on the central nervous system. Some special acids are active components of certain traditional Chinese medicines. For example, the antifungal utility of quercetin acid, found in the bark of Dendrobium candidum, is well-known. Derivatives of caffeic acid also exhibit certain biological activities. For instance, chlorogenic acid (Chlorogenic acid) is an active component in many traditional Chinese medicines and has antibacterial, cholagogic, and leukopenic effects.

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