Patient's question:
Hello, my wife is AB blood type, and I am O blood type. Is it easy for our child to suffer from ABO hemolytic disease? What kind of assistance do you need: Tell me the results a few times...Doctor's answer:
Hemolytic disease is a hereditary genetic disorder of type II hypersensitivity, primarily caused by blood type incompatibility between mother and fetus, leading to an autoimmune response. The dominant antigen inherited by the fetus from its grandparents is one that the mother lacks. When this antigen enters the mother's body, it produces immune antibodies (IgG), which can cross the placental villi into the fetal bloodstream. These antibodies bind to receptors on the surface of fetal red blood cells, activate the complement system, and destroy the cells, leading to hemolysis. This results in anemia, edema, hepatosplenomegaly, and progressive severe jaundice shortly after birth, potentially even causing bilirubin encephalopathy.