Is there any harm in the combination of O-type and B-type blood for the baby?

Patient's question:

The woman is type O blood, the man is type B blood, will it affect the baby?

Doctor's answer:

Hello: You are Type O blood, and your husband is Type B blood. You should be tested for the concentration of anti-A (or anti-B) antibodies. Neonatal hemolytic disease is often caused by incompatibility between the mother and baby's blood types.
After the mother becomes pregnant, both parents should have their blood types tested. ABO hemolytic disease in newborns is more common when the mother is Type O blood and the husband is Type A, B, or AB.
Generally, the first test is conducted at 16 weeks of pregnancy, the second at 28–30 weeks, and then every 2–4 weeks thereafter. Testing for blood type antibody titer during pregnancy can help detect and treat incompatibility between the mother and child early. In necessary cases, pregnancy may need to be terminated promptly.
Generally, pregnant women with blood type incompatibility should undergo regular monitoring at a specialized hospital to prevent and reduce harm.

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